MTHFR Test Details
Methylation+ Report Upgrade
The Methylation+ Report Upgrade is for individuals who have already sent in a gene test kit and received a report, but now want to add the full Methylation+ experience. This digital upgrade unlocks 10 comprehensive reports covering 60 unique genetic traits. You will gain deep insights into detoxification capacity, toxicant sensitivity, and inflammatory response, alongside personalized analysis of sleep patterns, nutrition, and emotional health. This is the ultimate roadmap for those ready to move beyond a single marker and understand the full complexity of their methylation and metabolic pathways.
To learn how your genetic information is protected, please review our Genetic Testing Privacy Statement.
Product details, kit components, reporting options, and packaging are subject to change by the manufacturer and may differ from the information shown on this site. Always verify instructions and warnings on the actual product label before use. This content is for reference only and does not constitute medical advice or a diagnosis. The genetic reports are for reference only and do not constitute medical advice, a diagnosis, or a clinical genetic consultation. We recommend consulting a licensed genetic counselor or healthcare professional to interpret your results within the context of your personal and family medical history. Genetic reports have not been evaluated by the FDA and are not intended to diagnose or cure any health condition.
Why Use Fenix Gene Tests?
Methylation+ Report Upgrade
What's Included with our
10 Detailed Methylation Reports
A comprehensive genetic panel that includes 68 genetic insights.
These assessments include:
- Everything in the Basic Report
- Expanded methylation pathway insights beyond MTHFR
- Genes influencing folate metabolism, B12, and choline needs
- Detoxification and glutathione-related pathways
- Genetic factors related to attention and cognitive traits
- Mood and emotional health patterns
- Sleep duration and circadian-related tendencies
- Micronutrient metabolism and nutrition-related pathways
- Performance and longevity resilience markers
- Inflammation & immune response patterns with CRP-related signals
Designed for individuals seeking a broader, systems-based view of the genes influencing methylation and long-term cognition.
Why MTHFR Matters
MTHFR (Methylenetetrahydrofolate Reductase) is a gene that provides instructions for making an enzyme involved in processing folate (vitamin B9) and supporting methylation, a foundational biochemical process that influences DNA repair, neurotransmitter production, and homocysteine balance. Variations in this gene may influence how efficiently the MTHFR enzyme functions in the body. There are two common variants of MTHFR: C677T and A1298C. You inherit one copy of the gene from each parent, which helps determine your overall enzyme activity.
Scientific research has identified associations between certain MTHFR variants and differences in folate metabolism and methylation efficiency. For example, the C677T variant has been associated with reduced enzyme activity in some individuals. However, MTHFR status alone does not determine health outcomes. Many factors, including diet, lifestyle, and other genetic and environmental influences, contribute to overall wellbeing. This test is intended for informational and educational purposes and is not intended to diagnose, treat, cure, or prevent any disease.
MTHFR testing provides information about your specific MTHFR genotype, including whether you carry common variants associated with differences in folate metabolism and methylation efficiency. Although MTHFR status does not diagnose or determine outcomes, it can offer helpful insight into how your body processes folate and regulates homocysteine levels.
For some individuals, this information can guide more intentional decisions around nutrition and supplementation. It may clarify whether bioactive folate, such as L-methylfolate (5-MTHF), is worth discussing as an alternative to synthetic folic acid.
People often choose MTHFR testing to:
- Understand whether they carry common MTHFR variants
- Make informed decisions about folate supplementation, including L-methylfolate
- Personalize nutrition and lifestyle strategies
- Explore how methylation may relate to mood, focus, and overall wellbeing
- Have more informed discussions with healthcare providers
Research suggests that lifestyle and nutritional factors play an important role in methylation balance. Knowing your MTHFR genotype can help you make practical, informed choices aligned with your biology.
This test is intended for informational and educational purposes and does not diagnose, treat, cure, or prevent any disease.
Your genetic information is protected using strict privacy and security standards.
Your DNA is used only to run your test and generate your personal results. It is not sold, shared for advertising, or used for unrelated research purposes.
Testing and analysis are conducted by a clinical laboratory partner that operates under HIPAA and GDPR privacy standards. Your data is protected using multi-level encryption, and additional safeguards are in place to reduce risk.
To further protect your privacy:
- Your personal identifying information is stored separately from your genetic data (data separation protocol).
- Genetic data is maintained in an anonymized genome database, meaning it is not stored in a way that directly identifies you.
- Results are shared only with you — and with your healthcare provider only if you request it.
Protecting your privacy and maintaining data security are core components of the testing process.
Take this test if you want to...
- Have deeper insight into your methylation & folate metabolism
- Get clarity if you’ve been told you “might have MTHFR”
- Make informed choices about folate supplements
- Support energy, mood, & focus with targeted nutrition
- Access personalized wellness insights easily
- Have more informed conversations with your doctors
Frequently Asked Questions
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Results appear in your portal at app.fenixhealthscience.com within 72 hours of purchase.
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Yes, your genetic information is used only to run your test and generate your personal results—it is not sold, shared for advertising, or used for unrelated research. Testing is processed by a clinical laboratory partner that operates under HIPAA and GDPR privacy standards. Your data is protected using multi-level encryption, and GeneMetrics uses data separation (your personal details are stored separately from your genetic data) to reduce risk even further. Genetic information is stored in an anonymized genome database, meaning it is not kept in a way that directly identifies you. Results are shared only with you (and your provider if you request it).
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Yes. You can unlock additional genetic reports anytime using the same test kit. No need to swab twice, just unlock the additional reports after your results are in.
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No. The reports are designed to be easy to understand, but they are also practitioner-friendly if you choose to share the results with your doctor.
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Your results are generated through a CLIA- and CAP-certified laboratory, two of the highest standards for clinical lab quality and accuracy. The testing and reporting process is backed by a multidisciplinary team spanning genetics, molecular biology, bioinformatics, clinical research, and medical data science. Just as importantly, the interpretation system is continuously refined using current, peer-reviewed scientific research and validated sources. The end goal is to provide results that are both technically reliable and translated into clear, evidence-based insights you can actually use in clinical and wellness decisions.
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