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Which Supplements Support Mental Health?

November 13, 2023


As Julia Rucklidge says in her TED Talk, “Nutrition matters. And if we’re really ready to get serious about mental health, we need to get serious about the critical role played by nutrition.”1

Individual nutrients have been the focus of many studies attempting to determine the role that they may play in normal brain function and mental health. Let’s look at each to discover just how they support mental well-being.

1. Omega-3s

Omega-3s are large molecules that help increase cell membrane fluidity and are the most well-studied nutrients for brain health. The n-3 LC-PUFAs (long-chain polyunsaturated fatty acids) EPA and DHA are commonly known to support mental health by facilitating neurotransmitter release, providing membrane structure and stability, and supporting advanced, integrated central nervous system activities such as attention, alertness, and motor coordination. EPA plays an important role in dopamine signaling, while DHA, the most abundant LC-PUFA in the brain, supports cell membrane fluidity and is highly concentrated at the end of the dendrites and supports synaptic release of neurotransmitters as well as improving neuronal signaling.

Deficient intake of omega-3s or excessive intake of omega-6s have been shown to affect the metabolism to favor omega-6 and thus further decrease the availability of both omega-3s DHA and EPA in the brain.

2. B Vitamins

L-methylfolate is the active, bioavailable form of B9 and folate that crosses the blood-brain barrier. L-methylfolate helps convert the amino acid tyrosine to dopamine, which is a neurotransmitter that is often deficient in those struggling with lack of focus and attention.

Pyridoxal-5’-phosphate is the active form of vitamin B6 that helps synthesize dopamine and serotonin.
Methylcobalamin is the active form of vitamin B12 that calms the nervous system and helps fatty acid synthesis.

3. Vitamin D3

We often know vitamin D as the sunshine vitamin, but vitamin D3 also plays a role in supporting mental health and brain development. It supports memory and helps maintain normal cognitive function.

4. Magnesium

Magnesium plays a key role in supporting brain health and in the formulation of neurotransmitters dopamine and serotonin. Magnesium deficiency can impair the brain’s ability to regulate important neurotransmitters like dopamine and serotonin, which can contribute to impaired sleep, irritability, lack of focus, mood shifts, and fatigue. Since dopamine signaling is important for normal attention and is often disrupted in individuals dealing with lack of focus and emotional balance, nutritional deficiencies of magnesium can exacerbate it.

B vitamins, vitamin D, and magnesium are the cofactors and precursors that support proper regulation of neurotransmitters, which are needed for optimal cognition.

4. Zinc

Zinc is a trace mineral that plays a role in regulating the dopamine transporter and supports memory and normal cognitive function. “In a 2017 study, researchers found that rats who had been given zinc supplements showed signs of improved memory and mental functioning.”3

5. Iron

Iron is important to mental health as a coenzyme of tyrosine hydroxylase, critical for dopamine synthesis—which is important to support normal attention. Iron is also important in its role in hemoglobin in the blood and transporting oxygen to the neuron. Iron deficiency impairs the brain’s ability to regulate important neurotransmitters like dopamine and serotonin, which can lead to loss of energy, lack of concentration, worry, and fatigue.

Accentrate® products contain Tissue-Targeted® EPA and DHA in phospholipid form, L-methylfolate, bioavailable forms of vitamins B6 and B12, vitamin D3, and riboflavin. They are formulated to provide lipid nutritional support essential for healthy focus, mood, emotional balance, and cognitive function.

MZI™ products contain the chelated form of the minerals magnesium, zinc, and iron and supports attention, focus, mood, and overall well-being. These minerals are in chelated form in order to be more absorbable/ bioavailable, to have reduced gastrointestinal issues, and to not have a metallic taste.

MZI™ is designed to provide a comprehensive approach when used with one of the Accentrate® products, but it can be used by itself for those looking to add mineral supplementation to their supplement regimen. When purchased in a bundle with any Accentrate® product, MZI™ is discounted 45%.

If you have any further questions about any of our products, please send us a message! We’d be happy to help you discover which product is best for your needs!

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References:

[1] YouTube. (n.d.). https://www.youtube.com/embed/3dqXHHCc5lA

[2] Life Time. (2023, October 4). 8 key supplements to boost your mental health — naturally. Experience Life. https://experiencelife.lifetime.life/article/8-key-supplements-to-boost-your-mental-health-naturally/

[3] Sandusky‐Beltran, L. A., Manchester, B. L., & McNay, E. C. (2017). Supplementation with zinc in rats enhances memory and reverses an age-dependent increase in plasma copper. Behavioural Brain Research, 333, 179–183. https://doi.org/10.1016/j.bbr.2017.07.007

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25 Reviews

Alissa

We are so pleased with this product! It has really helped my son!
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Tammy

I am so thankful for this product. We were using Vayarin and then they stopped shipping to the US. This product works the same as the other one. We are so thankful because it has been life changing for our son.
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Oliva

My husband and I see an improvement in our son’s ability to focus. We definitely want to continue Mark on his Accentrate110, and our confidence in Fenix is very high. We feel like you really care about us, our son, and your service.
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Jill

I cannot even begin to tell you how thankful my family is for Accentrate. My 8yo stopped taking it for 6 weeks and went from homework taking 15 minutes to taking 3 hours. 4 days back on it and he was back to normal. Ty for an amazing product that is keeping my guy balanced, and focused in school and at home!
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Mariano

I just wanted to thank you and your company for your commitment with your patients. Fourth months ago I wasn't able to receive your product directly in Puerto Rico and today I can. This is how your company differentiate from others, hearing the voice of your customer.
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Helen

We were Vayarin users until they stopped making it. We tried a few products that were supposed to be comparable, and they did not work for us. Then we found Accentrate. Vayarin worked perfectly for her, and so does Accentrate. We are very thankful for this product and customer service went beyond our expectations. Thank you!
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Pelac

Hello ,we used to use Vayarin for more than a year, than stopped produced it. This is our third mounth we use Accentrate. It’s even better than Vayarin! My son is 6 years old, the attention is now better. He speaks better too.
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Tammie

We are starting month 3 and we have seen lots of positive changes with emotional balance...she is easier to compromise with and a lot quicker to calm self. She has been helping around the house and helping with younger brother (hw with 6 yr old)…looking forward to many more positives…thank you.
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April

My 8 year old has struggles with focus. Sometimes he has a hard time following conversations and multi step instructions. He started Accentrate more than 2 months ago. His only comment was about the fishy burps! But now he takes them with a small snack and that isn’t a problem anymore. The main difference that we have seen is that he is having an easier time winding down at bedtime. He was having regular meltdowns but they seem to be fewer and farther between. I’m looking forward to seeing if there are any differences once school starts back up since we started at he very end of last school year.
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Lori

It has truly made a difference in our son’s life! We are so thankful to have it!
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Stephanie

We are nearing the end of our first 45 days of Accentrate for our two boys, and we are pleased to say that we did not skip a beat as we took our last Vayarin one day and we had the Accentrate ready for the next morning. It has been such a seamless transition-our boys (ages 10 and 11) have been able to remain focused and calm. My kids even enjoy taking Accentrate so much more than Vayarin. They would fight us every morning when they took Vayarin saying it “tasted fishy”. Accentrate has NO taste, it is only one pill versus the two pills of Vayarin, and it slides down so easily. The kids just think of it as an extra multi-vitamin because it is filled with so many extra nutrients. They actually take Accentrate willingly!
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Kassie J

I used to ask my son how he was feeling and he’d say, “it’s hard to explain mom, cause I don’t really know how I feel.” We use to call it being zombified. He has now been taking Accentrate for 3 months and the difference in the way he feels, acts, eats is something I prayed for every single day. Accentrate gives my child the vitamins that his brain and body needs. I am amazed at the improvement of his overall health and I have Accentrate to thank. Thank you, you’ve given my son his “life” back! I strongly recommend Accentrate to any parent.
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Vincent

I just wanted thank you guys for such an awesome product. We’ve been giving my son Accentrate for a little over a month and a half and we are really starting to see a big change in my son. Before, he could not focus at school, he used to get easily annoyed and bored. Also, he could not deal with transitions, fidgeting, and making noises and whining. He always wanted to do good in school, but physically and mentally he was having a difficult time. The school he goes to color codes a kid’s day by his behavior. Red is bad, yellow is ok, green is a good day, and purple is an awesome day. Everyday he would get either a yellow or red, with a green intermittently, forget about him bringing home a purple. Fast forward to now, and he brings home at least one purple during the week, and almost green everyday. He’s only had maybe 3 or 4 yellows since he has been on it. This week he has earned student of the week, the first time ever in his life. I used to stress out everyday because I knew when I picked up my son, I would have to hear how he had a terrible day. Well not anymore. Accentrate has helped my son and I, tremendously. I hope my story can help other parents. I started to research different alternatives and noticed some good reviews on Accentrate, that’s when I gave it a try. I can only imagine it will get even better with time. You definitely have a returning customer! Again, I couldn’t thank you guys enough.
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Melissa

My daughter just started Accentrate a week ago, she is 13, about 105 pounds, 5 feet. I have been having her take one in the morning and at night more to get it built up into her system. I must say that I can definitely tell that all of her spark plugs are beginning to fire. I’m so glad to find something that works for her.
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Mandy

We are on month 4 of Accentrate and my 11 year old girl seems so much better!
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M Tucker

We first tried Vayarin for three or so months. We didn’t notice any improvements. Then we found Accentrate, which has the phospholipid omega-3s that Vayarin has, but also has many other vitamins, minerals, and cofactors, and it was cheaper so we thought we’d give it a try. He’s been on it for more than six months. At his parent teacher conference and his report card, his teachers have said his attention and focus is improved. He’s still energetic at home and when we go out. But he can sit and read. He can sit in class and pay attention.
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Linda W

My son has been steadily improving with his behavior after 3 months on Accentrate. He has had far less episodes at home and at school. He went from failing in all subjects except gym and art, to passing all but one subject, which is reading.
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Kendra O.

I’ve spent at least a couple hundred dollars on different vitamins but they either tasted gross, too chewy or just couldn’t stomach them. I was introduced to Accentrate recently and thought we’d give it a try with our kids. They’ve been on it pretty regularly since summer and they say it helps them. I think it’s a solid product just by doing my own research on what vitamins are beneficial for children struggling with focus. This is the only vitamin that I have found that combines everything I was looking for. My kids range in age from 8-12.
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Jen P

My son has been taking Accentrate for the last four months. We’ve noticed improvement! The first benefits we noticed were calming in his behavior. He had fewer mood outbursts. He still did, but to a noticeably lessor extent. We have found recently, that we do not have to hassle him to sit and do his homework or reading either.
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Corrie

I actually purchased the 3-month supply for both me and my son, so we’re almost through the whole package. Hence, the additional order placed this week. I wanted us both to try it first for a month or so to determine if it’s something we’d like to keep taking. I have noticed some improvements in both of us – specifically in our ability to remember things. That’s been a big issue for both of us – something I’ve often referred to as being “scatter-brained.” I’ve noticed more changes in my son, so I think it’s impacting him more quickly than me, but I’ve seen enough to want to continue. As for the product itself, we love the packaging with the dates - it can be difficult to remember if we’ve taken medicine from day to day, so have a package that helps us manage that is so helpful!
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Cherie M

My son has been on Accentrate since June 2018. He is doing very well. The first thing we noticed was that he had significantly calmed down after a week of taking Accentrate. We didn’t notice improvements in focus or attention until later in September, but this might also be because he wasn’t in school in June or July. We’ve continually reordered because we feel it helps. It’s nice to take one pill instead of multiple supplements.
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Cherie M

The first thing we noticed was that he had significantly calmed down after a week of taking Accentrate. We’ve continually reordered because we feel it helps. It’s nice to take one pill instead of multiple supplements.
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Twinkie Mom

Accentrate has been very successful for our family. We started our son on it roughly 2 months ago and have noticed an improvement in his behaviour and his focus. Conversations with him are more enjoyable and he seems to be able to keep himself settled a bit more. We like that this product is healthy and that it feeds the brain everything it needs. For this reason, we’ve decided to put our other child on this supplement as well. A few weeks in, we coupled Accentrate with a gluten free and dairy free diet and noticed even greater improvements.
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Nikki

My son just finished up the three-month supply we bought and we are re-ordering. While this didn’t help him focus and concentrate like the medication did, there was enough improvement that I’d rather him be on a natural product than on an addictive substance with side effects. His teachers say that he is manageable and are supportive of our decision.
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Rebecca

We saw that fish oils, magnesium, multi-vitamins might help. And they did. But it was always hard having her take three different pills. This product is great because it’s one small pill with all these nutrients that we were already comfortable with. She didn’t like the fish oil pill, and said it was very fishy. This doesn’t taste fishy to her at all. The tracking component of the packaging is just brilliant. It’s helped us more than once notice we missed a day.
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