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People with ADHD have an Imbalance or Dysfunction in the Regulation of Neurotransmitters

June 19, 2019

Studies have shown that people with ADHD have an imbalance or dysfunction in the regulation of brain neurotransmitters, including dopamine, serotonin, and norepinephrine.[1], [2] Like Vayarin, Accentrate® addresses lipid imbalances by providing EPA and DHA conjugated to phospholipids, additionally, Accentrate supports proper neurotransmitter regulation by providing additional vitamins and minerals including vitamins B12, B( and B6, vitamin D3 and magnesium. Accentrates ingredients include:

L-methylfolate is the active, bioavailable form of B9 and folate that crosses the blood-brain barrier. L-methylfolate helps convert the amino acid tyrosine to dopamine, which is a neurotransmitter that is often deficient in people with ADHD.

Pyridoxal-5’-phosphate is the active form of vitamin B6 helps synthesize dopamine, norepinephrine, and serotonin.

Methylcobalamin is the active form of vitamin B12 that calms the nervous system and helps fatty acid synthesis.

Vitamin D is needed for regulation and expression of the neurotransmitter serotonin. 

Magnesium plays a key role in the formulation of neurotransmitters dopamine and serotonin. 

B vitamins, vitamin D, and magnesium are the cofactors and precursors that support proper regulation on neurotransmitters which are needed for optimal cognition.

[1] Blum, et. al., “Attention-deficit-hyperactivity Disorder and reward deficiency syndrome,” Neuropsychiatric Disease and Treatment 2008:4(5) 893-917, pg. 893-917.

[2] Patrick R, et. al., “Vitamin D and the Omega-3 Fatty Acids Control Serotonin Synthesis and Action, Part 2: Relevance for ADHD, Bipolar Disorder, Schizophrenia, and Impulsive Behavior.” FASEB Journal 29:2207–2222

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